‘Apparently PAX5, which regulates gene expression, B – cells to sufficient instructs the components of B-cell receptors to tumor growth even in the absence of foreign antigens, which normally trigger the immune response, spur ‘Thomas Tikhonenko said.
In lymphomas, instead to facilitate an appropriate immune response PAX5 Block B cell division switch in the ‘on’position, regardless of the exposure to antigens. This is due to increased production of several PAX5 important molecules that drives B-cell receptor, the B-cell expansion. Overexpression of PAX5 in mouse B-cell lymphoma cell lines increased tumor growth when these cells were transplanted into mice. For 5 years, the expression of PAX5 attenuates decreased cancer.The OncologySTAT Entity 10 includes the most influential names in the oncology including two the past presidents of American Society of Clinical Oncology the editors led by Dr. Schwarzenberg and comprises a team of oncology, for professional medical writer and oncology fellow.